| Powell Gap | 699 m | | Shenandoah-South Section |
| Strawberry Gap | | | South North Carolina Blue Ridge Crest |
| Sams Gap | 1446 m | | Central Great Smoky Mountains |
| Laurel Springs Gap | 882 m | | South Central Virginia Blue Ridge |
| Newfound Gap | 1539 m | | Newfound Mountain Region |
| Beahms Gap | | | Shenandoah-North Section |
| Browns Gap | 792 m | | Shenandoah-South Section |
| Horse Gap | | | South North Carolina Blue Ridge Crest |
| Wallace Gap | | | Nantahala Mountains |
| Flint Gap | 685 m | | Western Great Smoky Mountains |
| Tali Gap | 999 m | | Western Great Smoky Mountains |
| Cherry Gap | 1162 m | | Central Great Smoky Mountains |
| State Line Gap | | | Beech-Snake-Rich |
| Sal Patch Gap | 1093 m | | Balsam |
| Thorofare Gap | 316 m | | Shenandoah-Middle Section |
| Gum Gap | 933 m | | South North Carolina Blue Ridge Crest |
| Air Bellows Gap | 1136 m | | North North Carolina Blue Ridge Crest |
| Pady Gap | | | Newfound Mountain Region |
| Hickory Nut Gap | 887 m | | Western Great Smoky Mountains |
| Jones Gap | 886 m | | South North Carolina Blue Ridge Crest |