| Beasley Gap | 575 m | | South North Carolina Blue Ridge Crest |
| Shaw Grave Gap | 576 m | | Western Great Smoky Mountains |
| Rockfish Gap | 580 m | | South Central Virginia Blue Ridge |
| Line Rock Gap | 594 m | | South North Carolina Blue Ridge Crest |
| Whistling Gap | 599 m | | Western Great Smoky Mountains |
| Schoolhouse Gap | 600 m | | Western Great Smoky Mountains |
| Chilly Spring Gap | 601 m | | Western Great Smoky Mountains |
| Hickory Gap | 604 m | | South North Carolina Blue Ridge Crest |
| Deals Gap, North Carolina | 606 m | | Western Great Smoky Mountains |
| Wolfpen Gap | 614 m | | Western Great Smoky Mountains |
| Davenport Gap | 618 m | | Eastern Great Smoky Mountains |
| Lands Run Gap | 619 m | | Shenandoah-North Section |
| Scott Gap | 621 m | | Western Great Smoky Mountains |
| Upper Gap | 626 m | | South North Carolina Blue Ridge Crest |
| Dancing Gap | 628 m | | Western Great Smoky Mountains |
| Cherokee Gap | 629 m | | Balsam |
| Laurel Fork Gap | 636 m | | South North Carolina Blue Ridge Crest |
| Indian Gap | 637 m | | South Central Virginia Blue Ridge |
| Pump Gap | 640 m | | Bald Mountains |
| Crib Gap | 645 m | | Western Great Smoky Mountains |